A 12th-minute own goal from Luke Shaw saw the Spanish champions secure a 1-0 win at Old Trafford in the first leg and take a precious away goal back to Camp Nou.
But PSG netted two away goals in the last 16 before United pulled off a dramatic turnaround at the Parc des Princes, and Pogba is backing his team to do the same again.
The game is not done. Its not closed, the Frenchman, who missed the second leg against PSG, told MUTV after Saturdays win over West Ham.
I know its Barcelona, were playing in their home, but its never closed. Its still 90 minutes. The first half is gone, now its the second half.
Thats why we play football, to play against those teams, to play those games, Champions League quarter-final is just beautiful. We just have to enjoy it, give our best and trust ourselves.
Pogba netted a brace from the penalty spot to see off the Hammers and pick up three valuable points in the race for the top four on Saturday.